Last month the Food and Drug administration (FDA) formally put out an alert linking the risk of proton pump inhibitors (PPI) to clostridium difficile associated diarrhea. Though this has been known for some time it was only now that the concerns have been raised to the level of a safety alert.
The PPIs are often viewed as a safe class of drug and are often started for valid reasons but not stopped even after the original indication is gone. As the incidence of recurrent and refractory clostridium difficile becomes an every growing problem especially in the elderly who are often on PPIs it is becoming necessary to evaluate the risks and benefits of continuing PPIs long term.
Bottom line: Stop PPIs if there is not longer a clear reason to be taking them.
Safety Alerts for Human Medical Products > Proton Pump Inhibitors (PPIs) – Drug Safety Communication: Clostridium Difficile-Associated Diarrhea (CDAD) Can be Associated With Stomach Acid Drugs.
12 yr old otherwise healthy young man presents to his primary care physician office with a rash on the right calf for about a week.
Eli Lilly the manufacturer of Xigris drotrecogin alfa (activated) voluntarily withdrew it from the market today after further study did not show survival benefit.
Xigris did not show survival benefit
Egg allergy and Influenza vaccination – is it a real issue?
It appears that this may not be an issue after all. Updated recommendations from the CDC now support vaccinating most patients with egg allergies. Continue reading
I have had a lot of questions about blood cultures. How many set? How many minutes apart? And so on. I put together this post to settle some of the questions.
I just found out that Dr Stuart Segal, a close colleague and local family physician has been blogging too. He blogs about issues related to health that come up in his day to day practice. Being a family physician he certainly sees a broader range of health issues in his practice than I do and frequently writes commentary on frontline issues. Continue reading
This is a published 8 year study that followed over 477 thousand individuals looking for incidence of cancer. The results were interestingly that the intake of fresh fruit and vegetables make little if no difference in the rates of cancer. Interesting but not surprising findings. Remember statistically the best ways to maintain health is:
- Watch your weight, keep the BMI within normal range
- Dont smoke
- Get regular exercise
- Get treatment for hypertension and diabetes
- Keep up to date on vaccinations
- Avoid accidents
Fruit and vegetable intake and overall cancer risk… [J Natl Cancer Inst. 2010] – PubMed result.