Differences between intranasal live and inactivated injectable vaccine for influenza H1N1

Both vaccines are effective. They are manufactured with similar ingredients and both have chicken eggs in them.

Live intranasal vaccine
1. At least in children appears to provide 30-50% greater immune response.
2. Easy to administer- no needles
3. No evidence that transmission of live virus to contacts occurs. Still would recommend precautions if taking care of patient with recent bone marrow transplant.
4. Not approved for 49 years or pregnancy
5. Should be avoided if taking other live vaccines such as MMR, shingles vaccine at the same time
6. Inactivated vaccines can be given with it, such as seasonal influenza
7. Should avoid Tamiflu for 48 hours before and 2 weeks after vaccine

Inactivated injectable vaccine
1. Lower response rate
2. Needs injections
3. Better safety data in the over 49yrs and in pregnancy
4. Can be given ages 6 months and up
5. Can be given with other vaccines
6. Can be given to very immunocompromised patients
7. Tamiflu does not interfere with it

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